15+ Best Isekai Anime With A Female Lead That You Will Love

Most anime series nowadays have main male lead characters, especially in the isekai genre. However, there are also a handful of underrated isekai anime with strong female leads. In this article, we will be counting down 18 of these amazing animes where the main character is a girl.

From the 1990s until now, there have been several amazing isekai shows that match the requirement of this article. However, we are only going to be talking about the best of the best in this genre.

The titles listed below will be ranked according to their score on MyAnimeList. With that said, let’s jump into the listing.

List of the best Isekai anime series with female MC

1. Ascendance of a Bookworm
2. The Twelve Kingdoms
3. Saga of Tanya the Evil
4. Inuyasha
5. Fushigi Yuugi
6. Reincarnated as a Sword
7. BOFURI: I Don’t Want to Get Hurt, so I’ll Max Out My Defense.
8. My Next Life as a Villainess: All Routes Lead to Doom!
9. So I’m a spider, so what?
10. The Saint’s Magic Power Is Omnipotent
11. I’m the Villainess, So I’m Taming the Final Boss
12. The Bears Bear a Bare Kuma
13. Life With an Ordinary Guy Who Reincarnated Into a Total Fantasy Knockout
14. Jahy-sama Will Not Be Defeated!
15. Show By Rock!!
16. I’ve Been Killing Slimes for 300 Years and Maxed Out My Level
17. In the Land of Leadale
18. Didn’t I Say to Make My Abilities Average in the Next Life?!

18. Didn’t I Say to Make My Abilities Average in the Next Life?!

Genius people have to suffer from solitude and loneliness. Such is the case with our exceptional MC, who excels at everything she does. After her unexpected death, she gets a second chance at life, and she is granted one wish by the gods.

She chooses to be reborn as a normal girl with average skills and abilities. However, as if the gods ignored her request, she was born with insane magical potential.

Regardless, our girl has not given up as she enrolls in a hunting school far from her hometown. She also uses a fake name so that nobody recognizes her. She tries to hide her powers and live a normal life, but that is going to be difficult as she is faced with crazy situations that demand she use magic.

17. In the Land of Leadale

This is a neat isekai anime with a female lead that focuses on adventure rather than action.

The story follows a sickly girl whose life support fails, leading to her death. However, she soon finds herself in the fantasy lands of her favorite VRMMORPG.

Not only that, her character has the highest stats, making her overpowered. After that, our main character goes on adventures, explores lands, and makes new friends in this magical world.

16. I’ve Been Killing Slimes for 300 Years and Maxed Out My Level

This is one of the best slow-life isekai anime series that centers around a woman who gets a second chance at life after her death in the real world.

She worked herself to death, so she wanted to stay away from hard work at all costs. This is why she spends a hundred years only killing the lowest-level monster for a living and takes it easy.

However, thanks to her immortality, she only keeps leveling up to the point where she becomes overpowered. Regardless, her goal in life is the same as always. To live a peaceful, uneventful life.

But her peace is disrupted when a cast of characters get involved with her, and things start to get a little rowdy.

Recommended >> Best Slow Life Isekai Anime Recommendations For You!

15. Show By Rock!!

Show by Rock is a revolutionary isekai anime with a female MC that combines fantasy with music. This is probably the only Isekai show that has an idol theme in it.

The main character of this story is a girl who gets sucked into her favorite rhythm game.

Soon after, she learns that music has special powers in this world. Not only that, the person who can make the most wonderful music will be given the rights to rule the city.

However, there are some dark forces plotting something evil, and it is up to our main character to stop them and save the city with her music skills.

14. Jahy-sama Will Not Be Defeated!

Jahy-sama used to be the strongest being in the entire dark realm. As such, she was enjoying luxury and riches thanks to her overwhelming power.

However, one day, the mana crystal, which was the lifeline of the entire dark realm, got destroyed. Because of that, Jahy Sama turns into a child and has to live in the human realm.

This is a hilarious reverse-isekai anime series that will definitely make you laugh.

13. Life With an Ordinary Guy Who Reincarnated Into a Total Fantasy Knockout

This is kind of an isekai anime with a female lead, except the female lead is actually a guy. To put it in better terms, this is a genderbent anime where the male MC turns into a female thanks to a goddess’ power.

Together with his best friend, the duo has to adventure through an unknown fantasy land in order to defeat the demon lord.

What makes this more interesting is that the gender-swapped guys are cursed to be alluring and attractive to all men. So, his best friend, who knows he is actually a man beneath the beautiful appearance, has to resist the charm.

Overall, this is a hilarious anime series that will make you laugh out loud for sure.

Recommended >> 10 Interesting Anime Where a Guy Turns Into a Girl

12. The Bears Bear a Bare Kuma

The Bears Bear a Bare Kuma is a slice-of-life isekai anime series with a female protagonist who is overpowered.

The MC of this show is a rich girl who spends all her time playing VR games. One day, as a reward for spending so much time in the game, she gets some new items and access to a new map.

However, there is a twist. She is not able to log out. But the main character never liked her life to begin with, so she doesn’t really bother to try and go back to her real world.

Instead, she spends her time adventuring through the new fantasy land and making a name for herself.

11. I’m the Villainess, So I’m Taming the Final Boss

This is a rom-com isekai anime with a female protagonist where the MC is reincarnated into a dating sim game.

The main character does not realize this fact until one day, when memories of her past life come rushing into her head. Thanks to that, she now knows that she is reincarnated as the villainess, who is bound to die at the end of the game’s story.

Therefore, in order to escape her cruel fate, she has to befriend the last boss of the game and marry him.

10. The Saint’s Magic Power Is Omnipotent

This is one of the best anime series in the genre, where the main female character gets summoned into a magical world.

However, unlike the usual stories, there has been a mistake in her case. The people who summoned her accidentally brought two girls into their world. However, they only need one “Saint” who will save their world.

Soon after, the other girl is selected as the Saint, and our female lead is now stuck in a fantasy world with no particular goal. So she decides to learn more about the world’s herbs and potions.

However, she is still a saint with immense magical powers, which has had a great impact on her life there.

9. So I’m a spider, so what?

This is one of the greatest isekai animes with a strong female lead. Not to mention, our main character is not even a human for a good half of the show.

The story of this show revolves around a girl who gets reincarnated into a fantasy world along with her classmates. However, she was spawned in a dungeon as a spider.

The dungeon is a cruel place where everything tries to kill her. So in such a kill-or-be killed situation, she kills and devours every other monster and becomes overpowered.

But the true story only starts when her interactions with humans begin.

Recommended >> 10 Best Anime Where The MC Can Steal Powers & Abilities That You Must Watch

8. My Next Life as a Villainess: All Routes Lead to Doom!

This is a reverse Harem Isekai anime series where our main girl gets mysteriously transported into her favorite dating sim game.

However, she becomes the villainous character in the game, whose life is meant to be doomed. Having played the game for a long time, our MC knows all the misfortunes the villainess will face.

So she has to prepare in advance to make sure she is not doomed. But the best part about this show is the reverse harem moments, which get extremely hilarious.

7. BOFURI: I Don’t Want to Get Hurt, so I’ll Max Out My Defense

This is yet another isekai anime with a female MC with a VR game theme. The main character of this series has never played any games. However, she decided to try out a popular VR game because her friend had talked her into it.

Unlike other Isekai series, she does not get stuck in the game or anything. She can log out properly whenever she desires.

The story focuses on her adventures in the game as a playable character. Due to her obsession with defense, she becomes the most durable character in the game, being almost resistant to most attacks.

Overall, this is a hilarious action and adventure anime series with a strong female lead.

6. Reincarnated As A Sword

Reincarnated as a Sword is one of the most recently released anime on this list. The MC of this show is actually a guy who gets reincarnated as a sword in another world.

However, since he is a sword, he needs a wielder. And this wielder is none other than an adorable yet strong-willed cat girl.

Since the girl is actually a main character along with our male lead, I’m adding this anime to the list.

The story of this show is about our main character duo going on adventures and taking down bad guys in the process.

Recommended >> Top 20 Manga About Reincarnation You Must Read (No Anime Adaptations)

5. Fushigi Yuugi

Fushigi Yuugi is one of the most popular isekai anime with a female lead from the 90s. The show is a shoujo anime that mixes various themes like martial arts, romance, and comedy together.

The story is about a duo of girls who get sucked into another world after reading an ancient book.

After a series of events, one of the girls mysteriously returned to her world. Now, our MC, who is stuck in the other world, has to team up with a Chinese martial artist and go on adventures to summon the goddess.

If she can do that, the goddess will grant any of her wishes, which is her ticket back home.

4. Inuyasha

Inuyasha is yet another classic anime series that is very popular among veteran fans. The main character of this anime is a 15-year-old girl who gets transported to ancient times.

In this strange land, demons want to hunt her and claim a treasure that she is carrying unknowingly. However, thanks to a boy who is half-demon, half-human, she is saved.

Together, they have to adventure through towns and stop the evil forces from claiming the powerful treasure.

3. Saga Of Tanya The Evil

Saga of Tanya the Evil is one of the best isekai animes with a female protagonist. The story starts off with a salaryman who gets killed by one of his co-workers.

However, moments before his death, a being identifying itself as god appears before him. Being an atheist, he dismisses god and calls it “being X.”

Angered, the “being X” took it as a challenge and reincarnates him in another world as a girl named Tanya. Its goal is to give him enough suffering to the point that he will submit to God.

Now, Tanya has to participate in wars and rise through the ranks, all the while enduring the challenges thrown at her by the self-proclaimed gods.

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2. The Twelve Kingdoms

This is an underrated action-adventure anime with a red-haired girl as the main character. Thanks to her abnormally colored hair, she never fit in at school.

Her classmates only use her to get their job done and do not treat her like a person, thanks to her pushover attitude.

However, this all changes when one day a mysterious man appears in her classroom. He claims that she is the queen of his kingdom in another world. Before she could even process the entire thing, they got attacked by otherworldly beasts.

The man then takes her to the fantasy world, along with two of her classmates, by accident. They get separated, and it is up to our MC to find and save them.

1. Ascendance of a Bookworm

This show is, in my opinion, the greatest isekai anime with a female MC out there. The main character of this show is a girl who dies and gets transported into another world.

Her soul now resides inside a sickly young girl from a poor family. However, unlike the usual Isekai series, there is no magic in this anime initially.

She has to live an uncomfortable life without any of the luxuries of her previous life. There aren’t even any books for her to read in this world.

As a bookworm, this annoys her to the point where she decides to invent paper and create her own books. With that as her goal, she starts several businesses and monetizes her knowledge of the other world.

However, her life is about to take a huge twist when she is found to have mana, which could potentially kill her if nothing is done.

That’s it for this post! These are the top 18 isekai anime series where the main character is female.